using sysctl and sysfs to tweak /proc and /sys parameters can be useful in order to permanently set powertop suggestions or not to have to recompile the kernel for only one value change.

lm-profiler
helps disabling unneeded services

You can use sysctl to tweak the running kernel parameters (tweak /proc entries)
and /etc/sysctl.conf to apply these settings permanently
e.g. including in the abovementioned file the string

vm.dirty_writeback_centisecs=1500
increases the writeback centisecs

sysctl -p
makes changes effective

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To tweak /sys entries install sysfsutils package and edit file

/etc/sysfs.conf

e.g. to disable USB autosuspend you can either:

- recompile kernel without CONFIG_USB_SUSPEND
- add to sysfs.conf the line

module/usbcore/parameters/autosuspend = -1

also, to permanently switch off your wireless card (in case you do not have a phisical switch) set

bus/pci/devices/0000:02:02.0/rf_kill = 1

where 0000:02:02.0 is your wireless device address (you can see that via lspci -vvnn or lsusb -vvnn)